Long Acting Injectable Adapters for USP 2 & USP 4
Long-acting parenteral drug products are a popular choice for therapeutic areas requiring long term treatment.
These products range from dispersed systems such as drug suspensions and polymeric microspheres to in situ
forming polymeric implants. The lack of reliable drug release testing methods for these drug products not only
impedes the development of new drug products but also affects generic drug development. Current release
methods suffer from a range of problems such as high variability, poor reproducibility, poor discriminatory
ability, lack of depot-like structure formation (that could mimic the in vivo situation). Moreover, shorter duration
(less than a week) of release renders them unsuitable for in vitro-in vivo correlations (IVIVCs). To overcome these issues, PION LAI adapters were developed for both USP-type-II & IV apparatus
LAI for USP 2 (Dissolution Tester)
The Long Acting Injectable Adapter for USP 2 enables precise dissolution testing of long-acting injectable drugs and other extended-release dosage forms using the USP 2 Dissolution Apparatus. This guide covers unpacking, filter membrane activation, assembly, and sample loading, ensuring accurate preparation and reliable results. The adapter accommodates samples from 5–100 μL, making it ideal for pharmaceutical research and development involving injectable formulations.
LAI for USP 4 (Flow-through cells)
The Long Acting Injectable Adapters for USP 4 are designed to enable efficient dissolution testing of long-acting injectable drugs and other extended-release dosage forms using USP4 Flow-through cells. This user guide provides clear instructions on unpacking, cleaning, and proper sample loading for both 50μL and 1mL adapters. By following these steps, users can ensure reliable performance and accurate results for dissolution experiments, making the adapters ideal for pharmaceutical research and quality testing.
